Neotethyan suprasubduction zone ophiolites represent anomalous oceanic crust developed in older host basins during trench rollback cycles and later entrapped in orogenic belts as a result first of trench-passive margin and then continent–continent collisions. The Middle Jurassic Mirdita zone ophiolites in northern Albania constitute a critical transition between the dominantly mid-ocean ridge basalt (MORB)-related Early Jurassic Alpine–Apennine ophiolites in the west and supra-subduction zone (SSZ)-generated Cretaceous Eastern Mediterranean ophiolites in the east. The previously recognized Western- and Eastern-type ophiolites in the Mirdita zone display significant differences in their internal structure and pseudostratigraphy, but their geochemical affinities are more gradational in contrast to the earlier claims that these ophiolites may have formed in different tectonic settings at different times. Crosscutting relations of dike intrusions in the Eastern-type ophiolites indicate changes in the chemistry of magmatic plumbing systems from basaltic to andesitic, dacitic, rhyodacitic, and boninitic compositions through time and from west to east.